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A β-Fluoroamine Inhibitor of Purine Nucleoside Phosphorylase

✍ Scribed by Mason, Jennifer M.; Murkin, Andrew S.; Li, Lei; Schramm, Vern L.; Gainsford, Graeme J.; Skelton, Brian W.

Book ID
120479885
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
301 KB
Volume
51
Category
Article
ISSN
0022-2623

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## Abstract BCX‐1777, a novel inhibitor of the enzyme purine nucleoside phosphorylase, mimics the charged ribosyl oxocarbenium ion formed during the transition state of the enzyme‐catalyzed CN bond cleavage of nucleosides. BCX‐1777 is a slow‐onset, tight‐binding inhibitor with a __K__~__i__~^\*^ o