Synthesis of deuterated-BCX-1777, a pote
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Hollis S. Kezar III; Tracy L. Hutchison; Peter C. Tyler; Philip E. Morris Jr.
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Article
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2002
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John Wiley and Sons
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French
⚖ 112 KB
## Abstract BCX‐1777, a novel inhibitor of the enzyme purine nucleoside phosphorylase, mimics the charged ribosyl oxocarbenium ion formed during the transition state of the enzyme‐catalyzed CN bond cleavage of nucleosides. BCX‐1777 is a slow‐onset, tight‐binding inhibitor with a __K__~__i__~^\*^ o