𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)—a novel potent and orally active immunosuppressive agent

✍ Scribed by Shanta Bantia; Patrick J Miller; Cynthia D Parker; Sandya L Ananth; LaShun L Horn; John M Kilpatrick; Philip E Morris; Tracy L Hutchison; John A Montgomery; Jasbir S Sandhu


Book ID
117797853
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
133 KB
Volume
1
Category
Article
ISSN
1567-5769

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Synthesis of deuterated-BCX-1777, a pote
✍ Hollis S. Kezar III; Tracy L. Hutchison; Peter C. Tyler; Philip E. Morris Jr. 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 112 KB

## Abstract BCX‐1777, a novel inhibitor of the enzyme purine nucleoside phosphorylase, mimics the charged ribosyl oxocarbenium ion formed during the transition state of the enzyme‐catalyzed CN bond cleavage of nucleosides. BCX‐1777 is a slow‐onset, tight‐binding inhibitor with a __K__~__i__~^\*^ o