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Studies towards the total synthesis of rapamycin: Preparation of the C10C17 carbon unit

✍ Scribed by Steven V. Ley; Joanne Norman; Catherine Pinel


Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
297 KB
Volume
35
Category
Article
ISSN
0040-4039

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✦ Synopsis


Absbuct: The preparation of the C1o_Cl7 carbon unit of the immunosuppressive agent rapamycin is repxtcd via two routes leading to the substituted lactone 4.


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Studies towards the total synthesis of r
✍ James C. Anderson; Steven V. Ley; Stephen P. Marsden 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 304 KB

Abrfmcf: A convergent synthesis of the C22-C32 ption of rapamycin has been achieved by way of a Nozaki-Kishi coupling of vinyl iodide 14 with aldehydc 13. This aldehyde is available by the stereoselective addition of organometallic reagents to aldehyde 5, synthesised by either of two selenium mediat