Studies towards the total synthesis of rapamycin: Preparation of the C10C17 carbon unit
✍ Scribed by Steven V. Ley; Joanne Norman; Catherine Pinel
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 297 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Absbuct: The preparation of the C1o_Cl7 carbon unit of the immunosuppressive agent rapamycin is repxtcd via two routes leading to the substituted lactone 4.
📜 SIMILAR VOLUMES
Abrfmcf: A convergent synthesis of the C22-C32 ption of rapamycin has been achieved by way of a Nozaki-Kishi coupling of vinyl iodide 14 with aldehydc 13. This aldehyde is available by the stereoselective addition of organometallic reagents to aldehyde 5, synthesised by either of two selenium mediat
The synthesis of the cyclohexyl moiety of FK-505 and its coupling reaction with the CIo-CZ6fragment to provide an advanced synthetic intermediate(Clo\_Cjq) are described,