Rapamycin synthetic studies. 2. Elaboration of the C(10)-C(26) perimeter
β Scribed by Amos B. Smith III; Robert E. Maleczka Jr.; Johnnie L. Leazer Jr.; James W. Leahy; John A. McCauley; Stephen M. Condon
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 312 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
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Absbuct: The preparation of the C1o\_Cl7 carbon unit of the immunosuppressive agent rapamycin is repxtcd via two routes leading to the substituted lactone 4.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
A convcrgen~ stesuxon trolled synthesis of lhe cl-c26 podon of laulomyein has been
Model compounds (11 and 12) for the C1-C10 tetrahydropyran fragment of amphidinol 2 were prepared from (2S)-benzyloxypropanal in 9 steps. The synthetic route relied on diastereoselective diene-aldehyde cycloaddition, stereoselective C-allylation, and reagent based enantioselective aldehyde allylatio