𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Studies towards the total synthesis of rapamycin: Preparation of the cyclohexyl C33C42 fragment and further coupling to afford the C22C42 carbon unit

✍ Scribed by Cyrille Kouklovsky; Steven V. Ley; Stephen P. Marsden


Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
288 KB
Volume
35
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Studies towards the total synthesis of r
✍ James C. Anderson; Steven V. Ley; Stephen P. Marsden 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 304 KB

Abrfmcf: A convergent synthesis of the C22-C32 ption of rapamycin has been achieved by way of a Nozaki-Kishi coupling of vinyl iodide 14 with aldehydc 13. This aldehyde is available by the stereoselective addition of organometallic reagents to aldehyde 5, synthesised by either of two selenium mediat