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Studies on the Synthesis of Di- and Trisaccharide Analogues of Moenomycin A. Modifications in Unit E and in the Lipid Part

✍ Scribed by Guangbin Yang; Madina Mansourova; Lothar Hennig; Matthias Findeisen; Ramona Oehme; Sabine Giesa; Peter Welzel

Publisher: John Wiley and Sons
Year: 2004
Tongue: German
Weight: 381 KB
Volume: 87
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200490161

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✦ Synopsis

Abstract

Routes allowing the synthesis of moenomycin analogues with one modified sugar component and with new lipid parts were developed (see 10c, 12c, 16b, and 20b in Schemes 2–4). It is anticipated that such analogues will be useful for studying the mode of action of the moenomycin‐type transglycosylase inhibitors in detail and for preparing analogues with improved pharmacokinetic properties.

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