𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Evidence for the Combined Participation of a C10 and a C15 Precursor in the Biosynthesis of Moenocinol, the Lipid Part of the Moenomycin Antibiotics

✍ Scribed by Ines Neundorf; Christian Köhler; Lothar Hennig; Matthias Findeisen; Duilio Arigoni; Peter Welzel

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
127 KB
Volume
4
Category
Article
ISSN
1439-4227

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Upon feeding of [2‐^13^C,4‐^2^H]‐1‐deoxy‐D‐xylulose to Streptomyces ghanaensis, the deuterium label was retained exclusively at positions C‐7 and C‐17 in the moenocinol part of the moenomycin antibiotics. This result vindicates the hypothesis that the C~25~ structure of moenocinol is assembled from a C~10~ and a C~15~ precursor, each of which requires for its formation the involvement of a dimethylallyl diphosphate starter unit.

📜 SIMILAR VOLUMES