Studies on the preparation of camphorylidene derivatives of α-amino acids
✍ Scribed by Gamble, David L.; Hems, William P.; Ridge, Brian
- Book ID
- 120481273
- Publisher
- Royal Society of Chemistry
- Year
- 2001
- Weight
- 301 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1472-7781
- DOI
- 10.1039/b007659g
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Syntheses of a-fluoro-o-amino acid derivatives have been attempted from the viewpoints of their structural and biological interests. o-Amino esters were diazotised with i-AmONO or NaN02 to produce the corresponding diazo esters, which were treated with NBS and HF/pyridine to yield the a-bromo-a-fluo
Photooxidation of N-methoxy-2.4-disubstituted imidasoles, readily available by way of a three component cyclization followed by 0-allcylation, leads to stable acyl imines whhich react with various organometallics to afford cr,a-disubstituted amino acid m-amides in good yields. In an earlier communi