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Synthetic studies on the α-fluoro-α-amino acid derivatives

✍ Scribed by Takeuchi Yoshio; Masamoto Rumiko; Hagi Tohru; Koizumi Toru


Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
48 KB
Volume
29
Category
Article
ISSN
0022-1139

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✦ Synopsis


Syntheses of a-fluoro-o-amino acid derivatives have been attempted from the viewpoints of their structural and biological interests. o-Amino esters were diazotised with i-AmONO or NaN02 to produce the corresponding diazo esters, which were treated with NBS and HF/pyridine to yield the a-bromo-a-fluoro esters(R-CFBr-COOEt, la-c).


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