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Studies on the biological effects of deuteriated organic compounds

✍ Scribed by Nguyêñ-Dinh-Nguyên; Jan Vincent

Publisher
Springer Netherlands
Year
1976
Tongue
English
Weight
769 KB
Volume
58
Category
Article
ISSN
0301-486X

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✦ Synopsis

The antifugal activity of some perdeuteriated fatty acids, with normal chain 11 to 18 carbon atoms, was investigated on common dermatophytes Epidermophyton floccosum, Microsporum canis, Trichophyton mentagrophytes and T. rubrum under in vitro conditions. These studies were performed by dilution technique and with respiratory measurements, Perdeuteriation of some fatty acids increases their inhibitory effect on the dermatophyte growth. Perdeuteriated n-hendecanoic acid proved to be the most active of the substances tested. Possible mechanisms behind the enhanced antifungal activity due to the perdeuteriation of fatty acids are discussed.

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