Studies on enantioselective hydrolysis of the acetic ester of a secondary alcohol withArthrobacterlipase
β Scribed by Satoshi Mitsuda; Shigeyasu Nabeshima; Hideo Hirohara
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 297 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1432-0614
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π SIMILAR VOLUMES
The enantioselectivity and yield of lipase-catalysed hydrolyses of epoxy butanoates (4) depends on R. Sharpless oxidation of the secondary allylic alcohol (8,R2=Pr) established that in the lipase-catalysed hydrolysis of (4,R2=Pr) the threo-isomer gave higher ee than the erythroisomer.
Comparative studies of enantioselectivities and diastereoselectivities in the hydrolysis reactions of acylals and 50:50 threo-erythro mixtures of the esters of related secondary alcohols with Candida rugosa lipase gave significant information about the reactivity order in the enzymatic hydrolysis of
## Abstract Partial reduction of the esters and subsequent alkylation or vinylation provides the desired alcohols.