The effect of structural variations on the rates of elastase-catalyzed hydrolysis of model carbonate and carbamate esters was studied using HPLC. It is shown that branching in the immediate vicinity of the carbonate or carbamate functionally results in decreased hydrolysis rates. Whereas aryl carbon
β¦ LIBER β¦
Enantioselective lipase-catalyzed ester hydrolysis: Effects on rates and enantioselectivity from a variation of the ester structure
β Scribed by Dr. Jacek Bojarski; Joachim Oxelbark; Christina Andersson; Dr. Stig Allenmark
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 468 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0899-0042
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## Abstract Lipaseβcatalyzed enantioselective esterification between (__R__,__S__)βketoprofen and alkanediol in organic solvents was developed to produce (__S__)βketoprofen hydroxyalkyl esters. The acyl acceptor of 1,6βhexanediol for the resolution of (__R__,__S__)βketoprofen yielded only the enant