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Effects of structural variations on the rates of enzymatic and nonenzymatic hydrolysis of carbonate and carbamate esters

✍ Scribed by Munir N. Nassar; Bushra J. Agha; George A. Digenis

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 420 KB
Volume: 81
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600810321

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✦ Synopsis

The effect of structural variations on the rates of elastase-catalyzed hydrolysis of model carbonate and carbamate esters was studied using HPLC. It is shown that branching in the immediate vicinity of the carbonate or carbamate functionally results in decreased hydrolysis rates. Whereas aryl carbonates act as substrates for elastase, p-nitrophenyl butyl carbamate inhibits the enzyme. A novel method was developed for the entrapment and quantitation of 14CO2 produced upon hydrolysis of carbonyl-14C-labeled carbonate esters. This technique could be useful in studying the mechanism of enzymatic hydrolysis of this type of compound and has the potential of being adapted as a convenient method in the assessment of estrolytic activity of tissue homogenates.

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