Acetaminophen prodrugs II. Effect of structure and enzyme source on enzymatic and nonenzymatic hydrolysis of carbonate esters

Effects of structural variations on the

Effects of structural variations on the rates of enzymatic and nonenzymatic hydrolysis of carbonate and carbamate esters

✍ Munir N. Nassar; Bushra J. Agha; George A. Digenis 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 420 KB

The effect of structural variations on the rates of elastase-catalyzed hydrolysis of model carbonate and carbamate esters was studied using HPLC. It is shown that branching in the immediate vicinity of the carbonate or carbamate functionally results in decreased hydrolysis rates. Whereas aryl carbon