✦ LIBER ✦
Enantioselective lipase-catalysed hydrolysis of esters of epoxy secondary alcohols: An alternative to Sharpless oxidation
✍ Scribed by Brian A Marples; Mark Rogers-Evans
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 211 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The enantioselectivity and yield of lipase-catalysed hydrolyses of epoxy butanoates (4) depends on R. Sharpless oxidation of the secondary allylic alcohol (8,R2=Pr) established that in the lipase-catalysed hydrolysis of (4,R2=Pr) the threo-isomer gave higher ee than the erythroisomer.