✦ LIBER ✦

Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL

✍ Scribed by Oost, Thorsten K.; Belli, Barbara A.; Ding, Hong; Bruncko, Milan; Joseph, Mary K.; Kunzer, Aaron; Martineau, Darlene; McClellan, William J.; Mitten, Michael; Ng, Shi-Chung

Book ID: 115463098
Publisher: American Chemical Society
Year: 2007
Tongue: English
Weight: 755 KB
Volume: 50
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm061152t

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

412 Antitumor Activity of BM-1197, a Dua

412 Antitumor Activity of BM-1197, a Dual Inhibitor of Bcl-2 and Bcl-xL, in Small Cell Lung Cancer Tumors

✍ Bai, L.; Chen, J.; McEachern, D.; Liu, L.; Zhou, H.; Aguilar, A.; Yang, C.Y.; Me 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 62 KB

The Bcl-2/Bcl-XL/Bcl-w Inhibitor, Navito

The Bcl-2/Bcl-XL/Bcl-w Inhibitor, Navitoclax, Enhances the Activity of Chemotherapeutic Agents In Vitro and In Vivo

✍ Chen, J.; Jin, S.; Abraham, V.; Huang, X.; Liu, B.; Mitten, M. J.; Nimmer, P.; L 📂 Article 📅 2011 🏛 American Association for Cancer Research 🌐 English ⚖ 697 KB

‘Aerobically poised’ leukaemia cells are

‘Aerobically poised’ leukaemia cells are resistant to the mitochondrial toxin and BCL-2/BCL-XL inhibitor, ABT-737

✍ Miles, Gareth; Langlais, Claudia; MacFarlane, Marion; Cain, Kelvin 📂 Article 📅 2014 🏛 Elsevier Science 🌐 English ⚖ 65 KB

Design of Bcl-2 and Bcl-xL Inhibitors wi

Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New Scaffold

✍ Zhou, Haibin; Chen, Jianfang; Meagher, Jennifer L.; Yang, Chao-Yie; Aguilar, Ang 📂 Article 📅 2012 🏛 American Chemical Society 🌐 English ⚖ 854 KB

Susceptibility to drug-induced apoptosis

Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels

✍ Tudor, G; Aguilera, A; Halverson, D O; Laing, N D; Sausville, E A 📂 Article 📅 2000 🏛 Nature Publishing Group 🌐 English ⚖ 336 KB

Antisense Downregulation of the Apoptosi

Antisense Downregulation of the Apoptosis-related Bcl-2 and Bcl-xL Proteins: A New Approach to Cancer Therapy

✍ I. V. Lebedeva; C. A. Stein 📂 Article 📅 2000 🏛 SP MAIK Nauka/Interperiodica 🌐 English ⚖ 90 KB