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412 Antitumor Activity of BM-1197, a Dual Inhibitor of Bcl-2 and Bcl-xL, in Small Cell Lung Cancer Tumors

✍ Scribed by Bai, L.; Chen, J.; McEachern, D.; Liu, L.; Zhou, H.; Aguilar, A.; Yang, C.Y.; Meagher, J.L.; Stuckey, J.A.; Wang, S.


Book ID
122449153
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
62 KB
Volume
48
Category
Article
ISSN
0959-8049

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## Purpose Resistance to chemotherapy-induced apoptosis represents a major obstacle to cancer control. Overexpression of Bcl-2 is seen in multiple tumor types and targeting Bcl-2 may provide therapeutic benefit. A phase I study of navitoclax, a novel inhibitor of Bcl-2 family proteins, was conduct