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Antisense Downregulation of the Apoptosis-related Bcl-2 and Bcl-xL Proteins: A New Approach to Cancer Therapy

โœ Scribed by I. V. Lebedeva; C. A. Stein


Book ID
111567206
Publisher
SP MAIK Nauka/Interperiodica
Year
2000
Tongue
English
Weight
90 KB
Volume
34
Category
Article
ISSN
0026-8933

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โœ Besim Ogretmen; Ahmad R. Safa ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 797 KB

Recent studies have shown that high levels of the apoptosisrelated proteins bcl-2 and bcl-x, increase, while over-expression of bcl-x, or bax decreases, resistance to drugs that induce apoptosis in some human cancer cells. In the present report, we investigated whether expression of these apoptosis-