Studies in macrolide synthesis: A stereo
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Ian Paterson; M.Anne Lister; Roger D. Norcross
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Article
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1992
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Elsevier Science
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French
β 350 KB
The (9s)-macrolide 1 (P = TBS) was prepared in 14 steps (5% yield) with 63% overall ds starting from the ethyl ketone ($2. The Cl-C7 and Q-C13 segments, 3 and 4, were obtained via boron enolate aldol reactions mediated by (+)-and (-)-(Ipc)zBOTf, respectively. Conventional reduction conditions using