๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Studies in macrolide synthesis: an efficient synthesis of two chiral fragments of erythronolide a

โœ Scribed by Ian Paterson; Shailesh K Patel; John R. Porter

Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
133 KB
Volume
24
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Studies in macrolide synthesis: A stereo
Studies in macrolide synthesis: A stereocontrolled synthesis of a (9S)-macrolide intermediate for oleandomycin using chiral boron reagents.
โœ Ian Paterson; M.Anne Lister; Roger D. Norcross ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 350 KB

The (9s)-macrolide 1 (P = TBS) was prepared in 14 steps (5% yield) with 63% overall ds starting from the ethyl ketone ($2. The Cl-C7 and Q-C13 segments, 3 and 4, were obtained via boron enolate aldol reactions mediated by (+)-and (-)-(Ipc)zBOTf, respectively. Conventional reduction conditions using

Studies in macrolide synthesis: aldol co
Studies in macrolide synthesis: aldol condensations of chiral ethylketones via boron enolates.
โœ Ian Paterson; Cynthia K McClure ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 341 KB

A/do/ condensation of chiraal ethylketones 8 and 9,via their 9-BBN or "BupB eno/ates,with methacrolein and acetaldehyde gives mainly the &&&I adduct, 8 -+ 14 or 9 + 18. The chiral reagent (+)-(lpc)~OTf, in the presence of EL& is used to enhance the formation of 14 and 78, while

Studies in macrolide synthesis: Stereoco
Studies in macrolide synthesis: Stereocontrolled synthesis of a C1๎—ธC13 segment of concanamycin A
โœ Ian Paterson; Malcolm D. McLeod ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 329 KB

The Ct-Ct3 segment 6 of concanamycin A (1) was prepared by a highly stereocontrolled route (87% overall ds) in 16 steps from the ester 9. Key steps are the one-pot aldol/reduction, 8 + 12, and the HWB reaction, 18 + 19 + 6.8 1997 Elsevier Science Ltd.