A Concise Total Synthesis of the Lichen Macrolide (+)-Aspicilin.
β Scribed by Christophe Dubost; Istvan E. Marko; Thomas Ryckmans
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 12 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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## Abstract The asymmetric synthesis of the lichen macrolide (+)βaspicilin (1) was realised in 19 steps and with high stereoselectivity (de β₯ 91 %, ee β₯ 96%). Three of the four stereogenic centres were generated by employing the SAMP/RAMP hydrazone method. Key steps of the synthesis are the Ξ±,Ξ±β²βdo
## Abstract For Abstract see ChemInform Abstract in Full Text.