A Concise Total Synthesis of (+)-Heliotr
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Federica Pisaneschi; Francaย M. Cordero; Alberto Brandi
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Article
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2003
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John Wiley and Sons
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English
โ 91 KB
๐ 1 views
## Abstract A practical synthesis of the necine base (+)โheliotridine (**1**) is reported here. The present total synthesis is based on the highly selective 1,3โdipolar cycloaddition of (__S__)โ3โ__tert__โbutoxypyrroline __N__โoxide (**2**) to the commercially available ethyl 4โbromocrotonate, foll