𝔖 Bobbio Scriptorium
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Structure—activity relationships of omeprazole analogues and their mechanism of action

✍ Scribed by Per Lindberg; Arne Brändström; Björn Wallmark

Book ID
119111987
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
596 KB
Volume
8
Category
Article
ISSN
0165-6147

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Four novel ustiloxin D analogues were synthesized focusing on the size of the macrocyclic core, the stereochemistry at the bridgehead ether, and the enantiomer of ustiloxin D. All four were subjected to biological evaluation testing the inhibition of tubulin polymerization. Only 2,2-dimethyl-ustilox