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Structure-activity relationships of bisphosphonate analogues

✍ Scribed by F.P. Coxon; J. Rojas Navea; C.A. Stewart; J. Al Jaber; F.H. Ebetino ⁎; C.E. McKenna #; B.A. Kashemirov #; I. Mallard #; M.J. Rogers

Book ID
116319403
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
50 KB
Volume
38
Category
Article
ISSN
8756-3282

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Four novel ustiloxin D analogues were synthesized focusing on the size of the macrocyclic core, the stereochemistry at the bridgehead ether, and the enantiomer of ustiloxin D. All four were subjected to biological evaluation testing the inhibition of tubulin polymerization. Only 2,2-dimethyl-ustilox