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Structure-activity relationships of RGH-6643 analogues

✍ Scribed by G. Zólyomi; E. Birkás-Faigl; T. Haskó; E. Koltai; F. Andrási; P. Berzsenyi; E. Ezer; M. Nakamura

Book ID
115885346
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
130 KB
Volume
183
Category
Article
ISSN
0014-2999

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Four novel ustiloxin D analogues were synthesized focusing on the size of the macrocyclic core, the stereochemistry at the bridgehead ether, and the enantiomer of ustiloxin D. All four were subjected to biological evaluation testing the inhibition of tubulin polymerization. Only 2,2-dimethyl-ustilox