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Structure–activity relationships of ustiloxin analogues

✍ Scribed by Madeleine M. Joullié; Simon Berritt; Ernest Hamel

Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
632 KB
Volume
52
Category
Article
ISSN
0040-4039

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✦ Synopsis

Four novel ustiloxin D analogues were synthesized focusing on the size of the macrocyclic core, the stereochemistry at the bridgehead ether, and the enantiomer of ustiloxin D. All four were subjected to biological evaluation testing the inhibition of tubulin polymerization. Only 2,2-dimethyl-ustiloxin D retained any activity.

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