The structure of a new topoisomemse II inhibitor BE 10988 (1) isolated by our group has been determined
Structure of a new topoisomerase II inhibitor BE 10988
β Scribed by Hiroyuki Suda; Kimihiro Matsunaga; Shosuke Yamamura; Yoshikazu Shizuri
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 130 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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Synthesis of Elenic Acid, an Inhibitor of Topoisomerase II. -Stereospecific synthesis of title compound (VII) is achieved in five steps and an overall yield of 26% from iodophenol (I) and eicosyne (II), involving novel zipper reaction of alkyne (III) and one-pot elaboration of the terminal alkyne i
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