The structure of a new topoisomemse II inhibitor BE 10988 (1) isolated by our group has been determined
Synthesis of the topoisomerase II inhibitor BE 10988
β Scribed by Christopher J. Moody; Elizabeth Swann
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 129 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0040-4039
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Synthesis of Elenic Acid, an Inhibitor of Topoisomerase II. -Stereospecific synthesis of title compound (VII) is achieved in five steps and an overall yield of 26% from iodophenol (I) and eicosyne (II), involving novel zipper reaction of alkyne (III) and one-pot elaboration of the terminal alkyne i