𝔖 Bobbio Scriptorium
✦   LIBER   ✦

ChemInform Abstract: Synthesis of Elenic Acid, an Inhibitor of Topoisomerase II.

✍ Scribed by Rebecca C. Hoye; Alejandro S. Baigorria; Michael E. Danielson; Alexa A. Pragman; Hemaka A. Rajapakse

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
30
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

✦ Synopsis

Synthesis of Elenic Acid, an Inhibitor of Topoisomerase II.

-Stereospecific synthesis of title compound (VII) is achieved in five steps and an overall yield of 26% from iodophenol (I) and eicosyne (II), involving novel zipper reaction of alkyne (III) and one-pot elaboration of the terminal alkyne in (IV) to an (E)-Ξ²,Ξ³-unsaturated ester containing an Ξ±-stereocenter. This method is a general short, efficient route for the preparation of structural analogues.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Synthesis of Amino-
ChemInform Abstract: Synthesis of Amino-Acid Functionalized Ξ²-Carbolines as Topoisomerase II Inhibitors.
✍ Amy Morin Deveau; Marc A. Labroli; Christine M. Dieckhaus; Mary T. Barthen; Kirs πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 32 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

ChemInform Abstract: A Short Enantiosele
ChemInform Abstract: A Short Enantioselective Synthesis of the Topoisomerase II Inhibitor (+)-Eleutherin.
✍ Jennifer S. Gibson; Olivier Andrey; Margaret A. Brimble πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons βš– 17 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

ChemInform Abstract: Chemoenzymatic Synt
ChemInform Abstract: Chemoenzymatic Synthesis of Deoxy Analogues of the DNA Topoisomerase II Inhibitor Eleutherin and the 3C-Protease Inhibitor Thysanone.
✍ Prabhakar Bachu; Jonathan Sperry; Margaret A. Brimble πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons βš– 31 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v