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ChemInform Abstract: Synthesis of Amino-Acid Functionalized β-Carbolines as Topoisomerase II Inhibitors.

✍ Scribed by Amy Morin Deveau; Marc A. Labroli; Christine M. Dieckhaus; Mary T. Barthen; Kirsten S. Smith; Timothy L. Macdonald

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
32
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

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✍ Rebecca C. Hoye; Alejandro S. Baigorria; Michael E. Danielson; Alexa A. Pragman; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

Synthesis of Elenic Acid, an Inhibitor of Topoisomerase II. -Stereospecific synthesis of title compound (VII) is achieved in five steps and an overall yield of 26% from iodophenol (I) and eicosyne (II), involving novel zipper reaction of alkyne (III) and one-pot elaboration of the terminal alkyne i