Elenic acid, an inhibitor of Topoisomerase II, from a sponge, Plakinastrella sp.
β Scribed by Elen G. Juagdan; Raju S. Kalidindi; Paul J. Scheuer; Michelle Kelly-Borges
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 195 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Synthesis of Elenic Acid, an Inhibitor of Topoisomerase II. -Stereospecific synthesis of title compound (VII) is achieved in five steps and an overall yield of 26% from iodophenol (I) and eicosyne (II), involving novel zipper reaction of alkyne (III) and one-pot elaboration of the terminal alkyne i
Amphimic acids A (1) and B (2), novel unsaturated long-chain fatty acids possessing a cyclopropylidene group and inhibiting DNA topoisomerase I, have been isolated from an Australian sponge Amphimedon sp. Their structures were elucidated by spectroscopic analysis and chemical degradation. The enanti
Several C27-C30 unsaturated fatty acids have been isolated from an Australian sponge, Amphimedon sp., as human DNA topoisomerasΒ’ I inhibitors. Three of them, amphimic acids A (1)-C (3), are unusual fatty acids possessing a cyclopropylidene group, and one is a new C30 fatty acid 4. Their structures