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Amphimic acids, novel unsaturated C28 fatty acids as DNA topoisomerase I inhibitors from an Australian sponge Amphimedon sp.

✍ Scribed by Takayuki Nemoto; Makoto Ojika; Youji Sakagami

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
241 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Amphimic acids A (1) and B (2), novel unsaturated long-chain fatty acids possessing a cyclopropylidene group and inhibiting DNA topoisomerase I, have been isolated from an Australian sponge Amphimedon sp. Their structures were elucidated by spectroscopic analysis and chemical degradation. The enantioselective synthesis of 1 was carried out to determine the absolute configuration.

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Amphimic acids and related long-chain fatty acids as DNA topoisomerase I inhibitors from an Australian sponge, Amphimedon sp.: Isolation, structure, synthesis, and biological evaluation
✍ Takayuki Nemoto; Go Yoshino; Makoto Ojika; Youji Sakagami πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 907 KB

Several C27-C30 unsaturated fatty acids have been isolated from an Australian sponge, Amphimedon sp., as human DNA topoisomerasΒ’ I inhibitors. Three of them, amphimic acids A (1)-C (3), are unusual fatty acids possessing a cyclopropylidene group, and one is a new C30 fatty acid 4. Their structures