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Structure-based design of potent Grb2–SH2 domain antagonists not relying on phosphotyrosine mimics

✍ Scribed by Sheng Jiang; Peng Li; Megan L. Peach; Lakshman Bindu; Karen W. Worthy; Robert J. Fisher; Terrence R. Burke Jr.; Marc Nicklaus; Peter P. Roller

Book ID
116293527
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
234 KB
Volume
349
Category
Article
ISSN
0006-291X

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## Abstract A series of novel nonpeptide inhibitors of the pp60^c‐Src^ (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate moiety of phosphotyrosine (pTyr). Relative to an x‐ray structure of citrate complexed to the pTyr binding site of the Src SH2 do