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ChemInform Abstract: Structure-Based Design of a Nonpeptidic Antagonist of the SH2 Domain of Grb2.

โœ Scribed by Giorgio Caravatti; Joseph Rahuel; Brigitte Gay; Pascal Furet

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
30
Category
Article
ISSN
0931-7597

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Highly Potent Inhibitors of the Grb2-SH2 Domain. -The preparation of peptide mimetics (IX) (11 examples) with different substituents at the 3-indolyl-propylamine C-terminal group and their inhibition of the Grb2-SH2 domain is reported.