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Structure-Based Design of Novel Bicyclic Nonpeptide Inhibitors for the Src SH2 Domain

✍ Scribed by Shakespeare, William C.; Bohacek, Regine S.; Azimioara, Mihai D.; Macek, Karina J.; Luke, George P.; Dalgarno, David C.; Hatada, Marcos H.; Lu, Xiaode; Violette, Shelia M.; Bartlett, Catherine; Sawyer, Tomi K.

Book ID
125481251
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
876 KB
Volume
43
Category
Article
ISSN
0022-2623

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Structure-based design of novel nonpepti
Structure-based design of novel nonpeptide inhibitors of the Src SH2 domain: Phosphotyrosine mimetics exploiting multifunctional group replacement chemistry
✍ Raji Sundaramoorthi; Noriyuki Kawahata; Michael G. Yang; William C. Shakespeare; πŸ“‚ Article πŸ“… 2003 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 684 KB

## Abstract A series of novel nonpeptide inhibitors of the pp60^c‐Src^ (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate moiety of phosphotyrosine (pTyr). Relative to an x‐ray structure of citrate complexed to the pTyr binding site of the Src SH2 do