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Design, Synthesis, and Cocrystal Structure of a Nonpeptide Src SH2 Domain Ligand

✍ Scribed by Plummer, Mark S.; Holland, Debra R.; Shahripour, Aurash; Lunney, Elizabeth A.; Fergus, James H.; Marks, James S.; McConnell, Patrick; Mueller, W. Thomas; Sawyer, Tomi K.

Book ID
118029420
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
254 KB
Volume
40
Category
Article
ISSN
0022-2623

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## Abstract A series of novel nonpeptide inhibitors of the pp60^c‐Src^ (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate moiety of phosphotyrosine (pTyr). Relative to an x‐ray structure of citrate complexed to the pTyr binding site of the Src SH2 do