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Structure-Based Design of a Novel Series of Nonpeptide Ligands That Bind to the pp60 src SH2 Domain

✍ Scribed by Lunney, Elizabeth A.; Para, Kimberly S.; Rubin, J. Ronald; Humblet, Christine; Fergus, James H.; Marks, James S.; Sawyer, Tomi K.


Book ID
127126541
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
586 KB
Volume
119
Category
Article
ISSN
0002-7863

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Structure-based design of novel nonpepti
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## Abstract A series of novel nonpeptide inhibitors of the pp60^c‐Src^ (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate moiety of phosphotyrosine (pTyr). Relative to an x‐ray structure of citrate complexed to the pTyr binding site of the Src SH2 do