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ChemInform Abstract: Novel Phosphotyrosine Mimetics in the Design of Peptide Ligands for pp60src SH2 Domain.

✍ Scribed by A. SHAHRIPOUR; M. S. PLUMMER; E. A. LUNNEY; K. S. PARA; C. J. STANKOVIC; J. R. RUBIN; C. HUMBLET; J. H. FERGUS; J. S. MARKS; R. HERRERA; S. E. HUBBELL; A. R. SALTIEL; T. K. SAWYER


Book ID
112038989
Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
27
Category
Article
ISSN
0931-7597

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## Abstract A series of novel nonpeptide inhibitors of the pp60^c‐Src^ (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate moiety of phosphotyrosine (pTyr). Relative to an x‐ray structure of citrate complexed to the pTyr binding site of the Src SH2 do