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Novel phosphotyrosine mimetics in the design of peptide ligands for pp60src SH2 domain

✍ Scribed by Aurash Shahripour; Mark S. Plummer; Elizabeth A. Lunney; Kimberly S. Para; Charles J. Stankovic; John R. Rubin; Christine Humblet; James H. Fergus; James S. Marks; Roman Herrera; Susan E. Hubbell; Alan R. Saltiel; Tomi K. Sawyer


Book ID
108039022
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
339 KB
Volume
6
Category
Article
ISSN
0960-894X

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## Abstract A series of novel nonpeptide inhibitors of the pp60^c‐Src^ (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate moiety of phosphotyrosine (pTyr). Relative to an x‐ray structure of citrate complexed to the pTyr binding site of the Src SH2 do