✦ LIBER ✦

Structure-Based Design and Synthesis of Lipophilic 2,4-Diamino-6-Substituted Quinazolines and Their Evaluation as Inhibitors of Dihydrofolate Reductases and Potential Antitumor Agents1

✍ Scribed by Galitsky, Nikolai; Luft, Joe R.; Pangborn, Walter; Gangjee, Aleem; Vidwans, Anup P.; Vasudevan, Anil; Queener, Sherry F.; Kisliuk, Roy L.; Cody, Vivian; Li, Ruming

Book ID: 111987748
Publisher: American Chemical Society
Year: 1998
Tongue: English
Weight: 132 KB
Volume: 41
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm980081y

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Design, Synthesis and Biological Evaluat

Design, Synthesis and Biological Evaluation of 2,4-Diamino-6-methyl-5-substituted-pyrrolo[2,3-d]pyrimidines as Dihydrofolate Reductase Inhibitors.

✍ Aleem Gangjee; Hiteshkumar D. Jain; Sherry F. Queener 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 21 KB 👁 2 views

Design, synthesis and biological evaluat

Design, synthesis and biological evaluation of 2,4-diamino-6-methyl-5-substitutedpyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors

✍ Aleem Gangjee; Hiteshkumar D. Jain; Sherry F. Queener 📂 Article 📅 2005 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 75 KB

Nine novel nonclassical 2,4-diamino-6-methyl-5-thioarylsubstituted-7H-pyrrolo [2,3-d]pyrimidines 2-10 were synthesized as potential inhibitors of dihydrofolate reductase and as antitumor agents. The analogues contain various electron donating and electron withdrawing substituents on the phenylsulfan

Synthesis and Biological Evaluation of 2

Synthesis and Biological Evaluation of 2,4-Diamino-6-(arylaminomethyl)pyrido[2,3- d ]pyrimidines as Inhibitors of Pneumocystis c arinii and Toxoplasma g ondii Dihydrofolate Reductase and as Antiopportunistic Infection and Antitumor Agents 1

✍ Gangjee, Aleem; Adair, Ona O.; Queener, Sherry F. 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 120 KB

Nonclassical 2,4-Diamino-5-aryl-6-ethylp

Nonclassical 2,4-Diamino-5-aryl-6-ethylpyrimidine Antifolates: Activity as Inhibitors of Dihydrofolate Reductase from Pneumocystis carinii and Toxoplasma gondii and as Antitumor Agents

✍ Robson, Claire; Meek, Michelle A.; Grunwaldt, Jan-Dierk; Lambert, Peter A.; Quee 📂 Article 📅 1997 🏛 American Chemical Society 🌐 English ⚖ 227 KB

Selective Pneumocystis carinii Dihydrofo

Selective Pneumocystis carinii Dihydrofolate Reductase Inhibitors: Design, Synthesis, and Biological Evaluation of New 2,4-Diamino-5-substituted-furo[2,3- d ]pyrimidines 1

✍ Gangjee, Aleem; Guo, Xin; Queener, Sherry F.; Cody, Vivian; Galitsky, Nikolai; L 📂 Article 📅 1998 🏛 American Chemical Society 🌐 English ⚖ 152 KB

2,4-Diamino-5-deaza-6-Substituted Pyrido

2,4-Diamino-5-deaza-6-Substituted Pyrido[2,3-d]pyrimidine Antifolates as Potent and Selective Nonclassical Inhibitors of Dihydrofolate Reductases1,2

✍ Gangjee, Aleem; Vasudevan, Anil; Queener, Sherry F.; Kisliuk, Roy L. 📂 Article 📅 1996 🏛 American Chemical Society 🌐 English ⚖ 188 KB