ChemInform Abstract: Nonclassical 2,4-Di
โ
C. ROBSON; M. A. MEEK; J.-D. GRUNWALDT; P. A. LAMBERT; S. F. QUEENER; D. SCHMIDT
๐
Article
๐
2010
๐
John Wiley and Sons
โ 33 KB
๐ 1 views
Nonclassical 2,4-Diamino-5-aryl-6-ethylpyrimidine Antifolates: Activity as Inhibitors of Dihydrofolate Reductase from Pneumocystis carinii and Toxoplasma gondii and as Antitumor Agents. -Title compounds such as (I) exhibit potent inhibitory activity against dihydrofolate reductase (DHFR) from Toxop