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Nonclassical 2,4-Diamino-5-aryl-6-ethylpyrimidine Antifolates: Activity as Inhibitors of Dihydrofolate Reductase from Pneumocystis carinii and Toxoplasma gondii and as Antitumor Agents

โœ Scribed by Robson, Claire; Meek, Michelle A.; Grunwaldt, Jan-Dierk; Lambert, Peter A.; Queener, Sherry F.; Schmidt, Dirk; Griffin, Roger J.


Book ID
127373924
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
227 KB
Volume
40
Category
Article
ISSN
0022-2623

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ChemInform Abstract: Nonclassical 2,4-Di
โœ C. ROBSON; M. A. MEEK; J.-D. GRUNWALDT; P. A. LAMBERT; S. F. QUEENER; D. SCHMIDT ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB ๐Ÿ‘ 1 views

Nonclassical 2,4-Diamino-5-aryl-6-ethylpyrimidine Antifolates: Activity as Inhibitors of Dihydrofolate Reductase from Pneumocystis carinii and Toxoplasma gondii and as Antitumor Agents. -Title compounds such as (I) exhibit potent inhibitory activity against dihydrofolate reductase (DHFR) from Toxop