## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a โFull Textโ option. The original article is trackable v
ChemInform Abstract: Nonclassical 2,4-Diamino-8-deazafolate Analogues as Inhibitors of Dihydrofolate Reductases from Rat Liver, Pneumocystis carinii, and Toxoplasma gondii.
โ Scribed by A. GANGJEE; Y. ZHU; S. F. QUEENER; P. FRANCOM; A. D. BROOM
- Book ID
- 112036003
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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Nonclassical 2,4-Diamino-5-aryl-6-ethylpyrimidine Antifolates: Activity as Inhibitors of Dihydrofolate Reductase from Pneumocystis carinii and Toxoplasma gondii and as Antitumor Agents. -Title compounds such as (I) exhibit potent inhibitory activity against dihydrofolate reductase (DHFR) from Toxop
## Abstract The synthesis of four previously undescribed 2,4โdiaminopyrido[2,3โ__d__]pyrimidines (**3,4**) and 2,4โdiaminoquinazolines (**5,6**) with a bulky tricyclic aromatic group at the 6โposition is described. Condensation of dibenz[__b,f__]azepine with 2,4โdiaminoโ6โbromomethylpyrido[2,3โ__d_