ChemInform Abstract: Brominated Trimetrexate Analogues as Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase.
β Scribed by A. ROSOWSKY; C. E. MOTA; S. F. QUEENER
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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Nonclassical 2,4-Diamino-5-aryl-6-ethylpyrimidine Antifolates: Activity as Inhibitors of Dihydrofolate Reductase from Pneumocystis carinii and Toxoplasma gondii and as Antitumor Agents. -Title compounds such as (I) exhibit potent inhibitory activity against dihydrofolate reductase (DHFR) from Toxop