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ChemInform Abstract: Selective Pneumocystis carinii Dihydrofolate Reductase Inhibitors: Design, Synthesis, and Biological Evaluation of New 2,4-Diamino-5-substituted-furo[2,3-d]pyrimidines.

โœ Scribed by A. GANGJEE; X. GUO; S. F. QUEENER; V. CODY; N. GALITSKY; J. R. LUFT; W. PANGBORN


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
29
Category
Article
ISSN
0931-7597

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๐Ÿ“œ SIMILAR VOLUMES


ChemInform Abstract: Nonclassical 2,4-Di
โœ C. ROBSON; M. A. MEEK; J.-D. GRUNWALDT; P. A. LAMBERT; S. F. QUEENER; D. SCHMIDT ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB

Nonclassical 2,4-Diamino-5-aryl-6-ethylpyrimidine Antifolates: Activity as Inhibitors of Dihydrofolate Reductase from Pneumocystis carinii and Toxoplasma gondii and as Antitumor Agents. -Title compounds such as (I) exhibit potent inhibitory activity against dihydrofolate reductase (DHFR) from Toxop