Structure-activity relationships of a series of substituted 17α-hydroxy-9β, 10α-progesterones
✍ Scribed by J. Hartog; S.J. Halkes; L. Morsink; A.M. De Wachter; J.L.M.A. Schlatmann
- Book ID
- 116000274
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- English
- Weight
- 550 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0022-4731
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📜 SIMILAR VOLUMES
## Abstract An improved synthesis of the tritium labelled form of the new pharmacon DIENOGEST is described. The [^14^α,15α‐^3^‐H]DIENOGEST was obtained with a specific activity of 51 Ci/mmol and a radiochemical purity > 98%.
SYRTHESES of S-isotestosterone and the corresponding antbracene analogue using trsns-Q-hydroxy-S-methyl-%+ -(3'-methyl-+'-methorybenzo)-hydradane (I) were earlier 1 reported . The present corununicatlon describes the preparatlon of 178-hydroxp-des-A-androst-9-ene-Gone (IIR=OH) and
CH,(18) + 14-CH3; 2.07, s CH,( 4) (CDCI,);not yet crystalli~ed]~). Finally, 8 was converted by catalytic hydrogenation [5%-Pd/C in ethanol/triethylamine; + 11 and cyclisation [HCl in acetic acid] into 3-oxo-17~-acetoxy-14a-methyl-A4-8a,9B,lOa,13a-estrene (12) [m.p. 86-88'; -[ U ] D = + 1' (CHC1,).