The crystal structure of 21-bromo-9α-fluoro-11β-hydroxy-16α, 17α-(β-methyl-α-phenylmethylenedioxy)-4-pregnene-3.20, dione
✍ Scribed by Gerald W. Krakower; Barbara T. Keeler; J.Zanos Gougoutas
- Publisher
- Elsevier Science
- Year
- 1971
- Tongue
- French
- Weight
- 205 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
CH,(18) + 14-CH3; 2.07, s CH,( 4) (CDCI,);not yet crystalli~ed]~). Finally, 8 was converted by catalytic hydrogenation [5%-Pd/C in ethanol/triethylamine; + 11 and cyclisation [HCl in acetic acid] into 3-oxo-17~-acetoxy-14a-methyl-A4-8a,9B,lOa,13a-estrene (12) [m.p. 86-88'; -[ U ] D = + 1' (CHC1,).
HE ANDROGENIC steroids most effective in T the treatment of metastatic breast cancer have all been potent androgens. T o date, the less potent androgens have been less effective.3~4 Hence, when an androgen more potent than testosterone or methyltestosterone became available it was thought important
## Abstract Fluocinolone acetonide was tritiated by selective reduction of the 1,2‐double bond of the __O__‐protected analog under tritium, followed by re‐establishment of the 1,2‐double bond and deprotection. Protection of both hydroxyl functionalities was required. The product was obtained with s
The synthesis of gornma-aminobutyric acid (GABA) receptor ligands is important in finding new therapeutic agerts and in helping to understand the mode of action of GABA. Amongst others, the steroid derivative 3a-hydroxy-