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The total syntheses of 17β-hydroxy-des-a-androst-9-ene-5-one and 17β-hydroxy-10α-des-a-androstan-5-one

✍ Scribed by D.K. Banerjee; P.S.N. Murthy; V. Paul

Publisher
Elsevier Science
Year
1967
Tongue
French
Weight
120 KB
Volume
8
Category
Article
ISSN
0040-4039

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✦ Synopsis

SYRTHESES of S-isotestosterone and the corresponding antbracene analogue using trsns-Q-hydroxy-S-methyl-%+ -(3'-methyl-+'-methorybenzo)-hydradane (I) were earlier 1 reported . The present corununicatlon describes the preparatlon of 178-hydroxp-des-A-androst-9-ene-Gone (IIR=OH) and

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A Solution-Phase Combinatorial Parallel Synthesis of 3β-Amido-3α-hydroxy-5α-androstane-17-ones. -A two-level library of title compounds (IV) is prepared via reaction of oxirane (I) with 4 primary amines followed by treatment of each set with 4 aliphatic acyl chlorides. The purities of the products