## Abstract The photo‐oxidation of the title compound (**1**) is described. The isolated products are the result of a [2 + 2] oxygen addition to the olefinic double bond of the enamide.
Microbiological transformations of 3β-acetoxy-17a-aza-D-homoandrost- 5-en-17-one and 3β-acetoxy-androst-5-en-17-one with the fungus cunninghamella elegans
✍ Scribed by Trevor A. Crabb; Philip J. Dawson; Roger O. Williams
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 185 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## Abstract The photochemical behaviour of the title compound (**7**) is described. The obtained results indicate the high reactivity of the enamidic Δ^5^ double bond.
## Abstract magnified image A new industrially viable process for the preparation of 1β‐(__N__‐__tert__‐butyl carbamoyl)‐4‐aza‐5α‐androst‐1‐ene‐3‐one, also known by the generic name finasteride (**6**) from the new azaandrostane derivatives such as 1β‐(__N__‐__tert__‐butyl carbamoyl)‐4‐benzoyl‐4‐a
Catalytic reduction of 3j3-hydroxyandrost-4-ene-l7-one (I) with tritium gas gave a mixture of 3B-hydroxy-5a-androstane-17-one (11) and 3~-hydroxy-5cc-androstane-l7-one ( 1 1 1 ) . Oxidation of compound 1 1 followed by alkaline equilibration resulted in 37 % loss of label from position 4. 5a-Androsta