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A solution-phase combinatorial parallel synthesis of 3β-amido-3α-hydroxy-5α-androstane-17-ones

✍ Scribed by Rene´ Maltais; Donald Poirier

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
204 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A two-level library of 313-amido-3t~-hydroxy-5ct-androstane-17-one compounds was synthesized from a steroid precursor using the solution-phase parallel s),nthesis. The compounds were easily obtained in high purity by regioselective aminolysis of the oxwane intermediate followed by aeylation of the amine. Since oxiranes can begenerated from readily available ketones or alkenes, the proposed strategy give access to a large seres of compounds.

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