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Stress-specific signatures: expression profiling of p53 wild-type and -null human cells

✍ Scribed by Amundson, Sally A; Do, Khanh T; Vinikoor, Lisa; Koch-Paiz, Christine A; Bittner, Michael L; Trent, Jeffrey M; Meltzer, Paul; Fornace, Albert J


Book ID
110069702
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
222 KB
Volume
24
Category
Article
ISSN
0950-9232

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A puzzling finding in various human tumors, including glioblastoma multiforme (GBM), is the stabilization of wildtype (wt) p53 protein. The biological significance of this phenomenon and the mechanism by which it occurs are unexplained. Recent reports have revealed that mdm2 exerts its negative regu